Enhanced Antitumor Efficacy through an “AND gate” Reactive Oxygen?Species?Dependent pH?Responsive Nanomedicine Approach

enhanced efl listening skill through computer-assisted vocabulary glossing

abstract listening is a key and main tool in second language skill and its development is of prime concern to teachers and learners. furthermore, the application of technology in language classrooms has become more commonplace in the last fifty years. computer and the internet have made foreign language materials easy to access and use. so, the present study is an attempt to examine the effec...

Carbon Nanomaterials: Efficacy and Safety for Nanomedicine

Carbon nanomaterials, including fullerenes, carbon nanohorns, and carbon nanotubes, are increasingly being used in various fields owing to these materials' unique, size-dependent functions and physicochemical properties. Recently, because of their high variability and stability, carbon nanomaterials have been explored as a novel tool for the delivery of therapeutic molecules including peptide a...

Efficacy Enhanced by an Anti-IL-2 mAb IL-2 In Vivo Activities and Antitumor

IL-2 in vivo activities and antitumor efficacy enhanced by an anti-IL-2 mAb.

IL-2 is a potent immunostimulant and has been tested for clinical use, including in immunotherapy for cancers and HIV infection. Here we show that a widely used neutralizing anti-murine IL-2 mAb (S4B6) exhibits unexpected activities that enhance the treatment effects of IL-2 in vivo. Coinjection of the anti-IL-2 mAb with a plasmid carrying murine IL-2 cDNA significantly increased the serum IL-2...

Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin.

PURPOSE In vivo evaluation of good manufacturing practice-grade targeted liposomal doxorubicin (TVT-DOX), bound to a CD13 isoform expressed on the vasculature of solid tumors, in human tumor xenografts of neuroblastoma, ovarian cancer, and lung cancer. EXPERIMENTAL DESIGN Mice were implanted with lung, ovarian, or neuroblastoma tumor cells via the pulmonary, peritoneal, or orthotopic (adrenal...